Cerebrospinal Fluid Concentrations of Extracellular Matrix Proteins in Alzheimer’s Disease
نویسندگان
چکیده
منابع مشابه
Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer disease.
BACKGROUND Carbonylation is an irreversible oxidative modification of proteins that has been linked to various conditions of oxidative stress, aging, physiological disorders, and disease. Increased oxidative stress is thus also considered to play a role in the pathogenesis of age-related neurodegenerative disorders such as Alzheimer disease (AD). In addition, it has recently become evident that...
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Cerebrospinal fluid (CSF) -amyloid (A 1–42) is one of the key biological forms of -amyloid protein in brain tissue that inversely reflects brain amyloid burden with reduced concentrations in Alzheimer disease (AD) (1 ). Reductions in CSF A 1–42 have been shown to occur years before symptom onset (2 ) and to have good positive predictive value for progression from mild cognitive impairment to cl...
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BACKGROUND Alzheimer's disease (AD) has been associated with dysregulation of brain cholesterol trafficking and abnormal production of apolipoprotein E isoform 4 (apoE4). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein present in serum and cerebrospinal fluid (CSF) degrading the low-density lipoprotein receptor (LDLr) and other apoE-binding receptors involved in neuron choles...
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We examined the extracellular vesicle (EV) and RNA composition of pooled normal cerebrospinal fluid (CSF) samples and CSF from five major neurological disorders: Alzheimer's disease (AD), Parkinson's disease (PD), low-grade glioma (LGG), glioblastoma multiforme (GBM), and subarachnoid haemorrhage (SAH), representing neurodegenerative disease, cancer, and severe acute brain injury. We evaluated:...
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Oestradiol-178 is the most active oestrogen in premenopausal women. Assays for oestradiol are of value in the investigation of normal and abnormal ovarian function. Rapid oestradiol measurements are effective in monitoring ovulation induction in the treatment of female infertility, and sensitive assays facilitate the detection of lower oestradiol concentrations found in men and postmenopausal w...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2019
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-190187